Healthcare Transformation Case Studies

Learn from leading healthcare innovations. These case studies showcase AI breakthroughs, quality improvements, and care delivery transformations from top health systems.

Curated from health system newsrooms, peer-reviewed journals, and government sources. Each study links to the original publication for deeper learning.

AI & Technology2025

Cleveland Clinic AI Sepsis Detection: 10x Fewer False Alerts

Cleveland Clinic

Challenge:

Sepsis causes over 250,000 US deaths annually; traditional detection tools generate excessive false alerts, causing alert fatigue

Key Results:

  • 10-fold decrease in false alerts
  • 46% increase in identified sepsis cases
  • 7x more cases alerted before antibiotics needed
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Digital Health2025

Mayo Clinic Platform: 56 Million Patient Lives, 17% Digital Growth

Mayo Clinic

Challenge:

Scaling AI-enabled healthcare innovation while expanding access to expertise globally

Key Results:

  • 1.04 million digital appointments (+17% YoY)
  • 56 million patient lives in platform network
  • Solution developer ecosystem nearly doubled to 81
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Quality & Safety2024

NYU Langone: #1 in Nation for Quality Three Years Running

NYU Langone Health

Challenge:

Maintaining top-tier quality across expanding multi-hospital academic medical center network

Key Results:

  • Ranked #1 of 115 academic medical centers (Vizient)
  • 11 consecutive Leapfrog 'A' safety grades
  • CMS five-star rating for quality and safety
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Care Coordination2022

Penn Medicine: Automated Texting Cuts Readmissions 55%

Penn Medicine

Challenge:

High rates of post-discharge hospital readmissions due to fragmented transitional care

Key Results:

  • 55% reduction in 30-day readmissions
  • 41% less likely to need any acute care
  • 83% of patients engaged with the messages
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AI & Technology2025

Cleveland Clinic AI Documentation: 80+ Specialties Piloted

Cleveland Clinic

Challenge:

Administrative burden and documentation workload contributing to clinician burnout across health system

Key Results:

  • Piloted across 80+ specialties and subspecialties
  • Clinicians reported reduced burnout
  • Improved care coordination across specialties
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Operations2022

NYU Langone Brooklyn Merger: 33% Mortality Reduction

NYU Langone Health

Challenge:

Improving quality at acquired community hospital serving high-Medicaid population

Key Results:

  • In-hospital mortality dropped 33% (2.6% to 1.9%)
  • 39% improvement in central line infections
  • 33% reduction in catheter-associated UTIs
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AI & Technology2025

Mayo Clinic Digital Pathology: 20 Million Slides with AI

Mayo Clinic

Challenge:

Accelerating diagnostic speed and accuracy in pathology while addressing pathologist shortages

Key Results:

  • 20 million digital slide images digitized
  • Integration with treatments, genomics, imaging data
  • Faster, more personalized diagnostic insights
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Policy2024

CMS Innovation Center: Advancing Person-Centered Care

CMS Innovation Center

Challenge:

Ensuring value-based payment models drive quality improvement, not just cost reduction

Key Results:

  • 390 organizations launched in GUIDE dementia model
  • 40%+ of MCP participants are FQHCs
  • Safety-net participation increased 25% in 2024
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Policy2024

CMS Quality Strategy: Universal Foundation for Measurement

Centers for Medicare & Medicaid Services

Challenge:

Fragmented quality measures across Medicare, Medicaid, and Marketplace creating provider burden

Key Results:

  • Streamlined measures across all CMS programs
  • Focus on prevention, wellness, chronic disease
  • Innovation in patient-reported outcomes
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